2WTC

CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR

Summary for 2WTC

Entry DOI	10.2210/pdb2wtc/pdb
Related	1GXC 2CN5 2CN8 2W0J 2W7X 2WTD 2WTI 2WTJ
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK2, 4-[2-AMINO-5-(4-HYDROXY-3-METHOXYPHENYL)PYRIDIN-3-YL]BENZAMIDE, NITRATE ION, ... (4 entities in total)
Functional Keywords	transferase, kinase, cell cycle, li-fraumeni syndrome
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains	1
Total formula weight	37509.21
Authors	Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. (deposition date: 2009-09-15, release date: 2009-12-29, Last modification date: 2023-12-20)
Primary citation	Hilton, S.,Naud, S.,Caldwell, J.J.,Boxall, K.,Burns, S.,Anderson, V.E.,Antoni, L.,Allen, C.E.,Pearl, L.H.,Oliver, A.W.,Aherne, G.W.,Garrett, M.D.,Collins, I. Identification and Characterisation of 2-Aminopyridine Inhibitors of Checkpoint Kinase 2 Bioorg.Med.Chem., 18:707-, 2010 Cited by PubMed: 20022510 DOI: 10.1016/J.BMC.2009.11.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation