2WT8
Structure of the N-terminal BRCT domain of human microcephalin (Mcph1)
Summary for 2WT8
| Entry DOI | 10.2210/pdb2wt8/pdb |
| Descriptor | MICROCEPHALIN, ACETATE ION, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | cell cycle, chromosome condensation, dwarfism, polymorphism, microcephaly, phosphoprotein, mental retardation, primary microcephaly |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Cytoplasm, cytoskeleton, centrosome: Q8NEM0 |
| Total number of polymer chains | 4 |
| Total formula weight | 43425.58 |
| Authors | Richards, M.W.,Roe, S.M.,Bayliss, R. (deposition date: 2009-09-14, release date: 2009-12-01, Last modification date: 2011-07-13) |
| Primary citation | Richards, M.W.,Leung, J.W.C.,Roe, S.M.,Chen, J.,Bayliss, R. A Pocket on the Surface of the N-Terminal Brct Domain of Mcph1 is Required to Prevent Abnormal Chromosome Condensation. J.Mol.Biol., 395:908-, 2010 Cited by PubMed: 19925808DOI: 10.1016/J.JMB.2009.11.029 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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