2WQB

Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor

Summary for 2WQB

Entry DOI	10.2210/pdb2wqb/pdb
Related	1FVR 2GY5
Descriptor	ANGIOPOIETIN-1 RECEPTOR, 2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE (3 entities in total)
Functional Keywords	phosphoprotein, kinase, receptor, oncology, atp-binding, transferase, glycoprotein, tyrosine-protein kinase, phosphotransferase, nucleotide-binding, disease mutation, thiazolopyrimidine
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	37383.74
Authors	Brassington, C.,Breed, J.,Buttar, D.,Fitzek, M.,Forder, C.,Hassall, L.,Hayter, B.R.,Jones, C.D.,Luke, R.W.A.,McCall, E.,McCoull, W.,Norman, R.,Paterson, D.,McMiken, H.,Rowsell, S.,Tucker, J.A. (deposition date: 2009-08-18, release date: 2009-11-03, Last modification date: 2023-12-20)
Primary citation	Luke, R.W.,Ballard, P.,Buttar, D.,Campbell, L.,Curwen, J.,Emery, S.C.,Griffen, A.M.,Hassall, L.,Hayter, B.R.,Jones, C.D.,Mccoull, W.,Mellor, M.,Swain, M.L.,Tucker, J.A. Novel Thienopyrimidine and Thiazolopyrimidine Kinase Inhibitors with Activity Against Tie-2 in Vitro and in Vivo. Bioorg.Med.Chem.Lett., 19:6670-, 2009 Cited by PubMed: 19854647 DOI: 10.1016/J.BMCL.2009.10.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation