Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2WPE

Trypanosoma brucei trypanothione reductase in complex with 3,4- dihydroquinazoline inhibitor (DDD00073359)

Summary for 2WPE
Entry DOI10.2210/pdb2wpe/pdb
Related2WOI 2WOV 2WOW 2WP5 2WP6 2WPC 2WPF
DescriptorTRYPANOTHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, N-{2-[(4S)-6-CHLORO-2-METHYL-4-PHENYLQUINAZOLIN-3(4H)-YL]ETHYL}FURAN-2-CARBOXAMIDE, ... (8 entities in total)
Functional Keywordsoxidoreductase, trypanosomiasis, sleeping sickness, redox-active center
Biological sourceTRYPANOSOMA BRUCEI
Total number of polymer chains4
Total formula weight219676.00
Authors
Alphey, M.S.,Patterson, S.,Fairlamb, A.H. (deposition date: 2009-08-06, release date: 2010-10-13, Last modification date: 2023-12-20)
Primary citationPatterson, S.,Alphey, M.S.,Jones, D.C.,Shanks, E.J.,Street, I.P.,Frearson, J.A.,Wyatt, P.G.,Gilbert, I.H.,Fairlamb, A.H.
Dihydroquinazolines as a Novel Class of Trypanosoma Brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of Their Binding Mode by Protein Crystallography.
J.Med.Chem., 54:6514-, 2011
Cited by
PubMed: 21851087
DOI: 10.1021/JM200312V
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon