2WOU

ALK5 IN COMPLEX WITH 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide

Summary for 2WOU

Entry DOI	10.2210/pdb2wou/pdb
Related	1B6C 1IAS 1PY5 1RW8 1VJY 2WOT
Descriptor	TGF-BETA RECEPTOR TYPE-1, 1,2-ETHANEDIOL, 4-({4-[(2,6-DIMETHYLPYRIDIN-3-YL)OXY]PYRIDIN-2-YL}AMINO)BENZENESULFONAMIDE, ... (4 entities in total)
Functional Keywords	transferase, serine/threonine-protein kinase, alk, atp-binding, kinase inhibitor, nucleotide-binding, tgf beta type i receptor
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	35371.69
Authors	Debreczeni, J.E.,Norman, R.A.,Goldberg, F.W.,Ward, R.A.,Finlay, R.,Powell, S.J.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L. (deposition date: 2009-07-28, release date: 2009-09-22, Last modification date: 2019-05-08)
Primary citation	Goldberg, F.W.,Ward, R.A.,Powell, S.J.,Debreczeni, J.E.,Norman, R.A.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L. Rapid Generation of a High Quality Lead for Transforming Growth Factor-Beta (Tgf-Beta) Type I Receptor (Alk5). J.Med.Chem., 52:7901-, 2009 Cited by PubMed: 19736928 DOI: 10.1021/JM900807W PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation