2WOT

ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin-2-amine

Summary for 2WOT

• Entry DOI: 10.2210/pdb2wot/pdb
• Related: 1B6C 1IAS 1PY5 1RW8 1VJY 2WOU
• Descriptor: TGF-BETA RECEPTOR TYPE-1, 4-[(5,6-DIMETHYL-2,2'-BIPYRIDIN-3-YL)OXY]-N-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-2-AMINE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: alk5, kinase, membrane, receptor, manganese, serine/threonine-protein kinase, kinase inhibitor, disease mutation, craniosynostosis, nucleotide-binding, tgf beta type i receptor, phosphoprotein, disulfide bond, aortic aneurysm, glycoprotein, metal-binding, transmembrane, atp-binding, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 35459.78

Authors

Norman, R.A.,Debreczeni, J.E.,Goldberg, F.W.,Ward, R.A.,Finlay, R.,Powell, S.J.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L. (deposition date: 2009-07-28, release date: 2009-09-22, Last modification date: 2019-05-08)

• Primary citation: Goldberg, F.W.,Ward, R.A.,Powell, S.J.,Debreczeni, J.E.,Norman, R.A.,Roberts, N.J.,Dishington, A.P.,Gingell, H.J.,Wickson, K.F.,Roberts, A.L.; Rapid Generation of a High Quality Lead for Transforming Growth Factor-Beta (Tgf-Beta) Type I Receptor (Alk5).; J.Med.Chem., 52:7901-, 2009; PubMed: 19736928; DOI: 10.1021/JM900807W

Experimental method

X-RAY DIFFRACTION (1.85 Å)