2WKM

X-ray Structure of PHA-00665752 bound to the kinase domain of c-Met

Summary for 2WKM

Entry DOI	10.2210/pdb2wkm/pdb
Related	1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2CEW 2G15 2UZX 2UZY 2WD1 2WGJ
Descriptor	HEPATOCYTE GROWTH FACTOR RECEPTOR, (3Z)-5-[(2,6-DICHLOROBENZYL)SULFONYL]-3-[(3,5-DIMETHYL-4-{[(2S)-2-(PYRROLIDIN-1-YLMETHYL)PYRROLIDIN-1-YL]CARBONYL}-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE (3 entities in total)
Functional Keywords	hepatocyte growth factor receptor, c-met, kinase, inhibitor, transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	35521.02
Authors	McTigue, M.,Grodsky, N.,Ryan, K.,Cui, J.J. (deposition date: 2009-06-15, release date: 2010-08-25, Last modification date: 2023-12-13)
Primary citation	Cui, J.J.,Tran-Dube, M.,Shen, H.,Nambu, M.,Kung, P.P.,Pairish, M.,Jia, L.,Meng, J.,Funk, L.,Botrous, I.,Mctigue, M.,Grodsky, N.,Ryan, K.,Padrique, E.,Alton, G.,Timofeevski, S.,Yamazaki, S.,Li, Q.,Zou, H.,Christensen, J.,Mroczkowski, B.,Bender, S.,Kania, R.S.,Edwards, M.P. Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk). J.Med.Chem, 54:6342-, 2011 Cited by PubMed: 21812414 DOI: 10.1021/JM2007613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation