2WK5

Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil

Summary for 2WK5

Entry DOI	10.2210/pdb2wk5/pdb
Related	1UOU 2J0F 2WK6
Descriptor	THYMIDINE PHOSPHORYLASE, GLYCEROL (3 entities in total)
Functional Keywords	glycosyltransferase, developmental protein, angiogenesis, 5-iodouracil, growth factor, enzyme kinetics, differentiation, disease mutation, thymidine phosphorylase, chemotaxis, transferase, mutagenesis, polymorphism
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	4
Total formula weight	200109.30
Authors	Mitsiki, E.,Papageorgiou, A.C.,Iyer, S.,Thiyagarajan, N.,Prior, S.H.,Sleep, D.,Finnis, C.,Acharya, K.R. (deposition date: 2009-06-05, release date: 2009-07-07, Last modification date: 2023-12-13)
Primary citation	Mitsiki, E.,Papageorgiou, A.C.,Iyer, S.,Thiyagarajan, N.,Prior, S.H.,Sleep, D.,Finnis, C.,Acharya, K.R. Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil. Biochem.Biophys.Res.Commun., 386:666-, 2009 Cited by PubMed: 19555658 DOI: 10.1016/J.BBRC.2009.06.104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation