2WJO

human Bace (beta secretase) in complex with Cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4H-quinazolin-3-yl)-2 -cyclohexyl-ethyl)- amide

Summary for 2WJO

Entry DOI	10.2210/pdb2wjo/pdb
Related	1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2FDP 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4
Descriptor	BETA-SECRETASE 1, 2-AMINO-3-{(1R)-1-CYCLOHEXYL-2-[(CYCLOHEXYLCARBONYL)AMINO]ETHYL}-6-PHENOXYQUINAZOLIN-3-IUM (3 entities in total)
Functional Keywords	zymogen, membrane, hydrolase, glycoprotein, transmembrane
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	1
Total formula weight	46465.34
Authors	Mathieu, M.,Dupuy, A.S. (deposition date: 2009-05-28, release date: 2010-03-02, Last modification date: 2011-07-13)
Primary citation	Nicholls, A.,Mcgaughey, G.B.,Sheridan, R.P.,Good, A.C.,Warren, G.,Mathieu, M.,Muchmore, S.W.,Brown, S.P.,Grant, J.A.,Haigh, J.A.,Nevins, N.,Jain, A.N.,Kelley, B. Molecular Shape and Medicinal Chemistry: A Perspective. J.Med.Chem., 53:3862-, 2010 Cited by PubMed: 20158188 DOI: 10.1021/JM900818S PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation