2WD7
PTERIDINE REDUCTASE 1 (PTR1) FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH NADP AND DDD00066750
Summary for 2WD7
| Entry DOI | 10.2210/pdb2wd7/pdb |
| Related | 2C7V 2VZ0 2WD8 |
| Descriptor | PTERIDINE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-chloro-1H-benzimidazol-2-amine, ... (5 entities in total) |
| Functional Keywords | short-chain dehydrogenase/reductase, drug discovery, oxidoreductase, trypanosomatids, pteridine reductase, methotrexate resistance |
| Biological source | TRYPANOSOMA BRUCEI BRUCEI More |
| Total number of polymer chains | 4 |
| Total formula weight | 117685.77 |
| Authors | Robinson, D.A.,Wyatt, P.G.,Spinks, D.,Brenk, R. (deposition date: 2009-03-20, release date: 2009-06-30, Last modification date: 2023-12-13) |
| Primary citation | Mpamhanga, C.P.,Spinks, D.,Tulloch, L.B.,Shanks, E.J.,Robinson, D.A.,Collie, I.T.,Fairlamb, A.H.,Wyatt, P.G.,Frearson, J.A.,Hunter, W.N.,Gilbert, I.H.,Brenk, R. One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening. J.Med.Chem., 52:4454-, 2009 Cited by PubMed: 19527033DOI: 10.1021/JM900414X PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
