2WD1

Human c-Met Kinase in complex with azaindole inhibitor

Summary for 2WD1

Entry DOI	10.2210/pdb2wd1/pdb
Related	1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2CEW 2G15 2UZX 2UZY
Descriptor	HEPATOCYTE GROWTH FACTOR RECEPTOR, 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDE, GAMMA-BUTYROLACTONE, ... (4 entities in total)
Functional Keywords	human kinase, c-met, azaindole, inhibitor, transferase, kinase, nucleotide-binding, atp-binding, tyrosine-protein kinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Membrane; Single-pass type I membrane protein: P08581
Total number of polymer chains	1
Total formula weight	33566.92
Authors	Porter, J.,Lumb, S.,Franklin, R.J.,Gascon-Simorte, J.M.,Calmiano, M.,Le Riche, K.,Lallemand, B.,Keyaerts, J.,Edwards, H.,Maloney, A.,Delgado, J.,King, L.,Foley, A.,Lecomte, F.,Reuberson, J.,Meier, C.,Batchelor, M. (deposition date: 2009-03-19, release date: 2009-04-28, Last modification date: 2011-07-13)
Primary citation	Porter, J.,Lumb, S.,Franklin, R.J.,Gascon-Simorte, J.M.,Calmiano, M.,Riche, K.L.,Lallemand, B.,Keyaerts, J.,Edwards, H.,Maloney, A.,Delgado, J.,King, L.,Foley, A.,Lecomte, F.,Reuberson, J.,Meier, C.,Batchelor, M. Discovery of 4-Azaindoles as Novel Inhibitors of C- met Kinase. Bioorg.Med.Chem.Lett., 19:2780-, 2009 Cited by PubMed: 19369077 DOI: 10.1016/J.BMCL.2009.03.110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation