2W9F

Crystal Structure of CDK4 in complex with a D-type cyclin

Summary for 2W9F

Entry DOI	10.2210/pdb2w9f/pdb
Related	1LD2 2W96 2W99
Descriptor	G1/S-SPECIFIC CYCLIN-D1, CELL DIVISION PROTEIN KINASE 4 (3 entities in total)
Functional Keywords	serine/threonine-protein kinase, chromosomal rearrangement, atp-binding, transferase, polymorphism, cell division, proto-oncogene, phosphoprotein, disease mutation, nucleotide-binding, cyclin dependent kinase, kinase, cyclin, oncology, cell cycle, drug desgn
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	65611.03
Authors	Day, P.J.,Cleasby, A.,Tickle, I.J.,Reilly, M.O.,Coyle, J.E.,Holding, F.P.,McMenamin, R.L.,Yon, J.,Chopra, R.,Lengauer, C.,Jhoti, H. (deposition date: 2009-01-23, release date: 2009-03-10, Last modification date: 2023-12-13)
Primary citation	Day, P.J.,Cleasby, A.,Tickle, I.J.,O'Reilly, M.,Coyle, J.E.,Holding, F.P.,Mcmenamin, R.L.,Yon, J.,Chopra, R.,Lengauer, C.,Jhoti, H. Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin. Proc.Natl.Acad.Sci.USA, 106:4166-, 2009 Cited by PubMed: 19237565 DOI: 10.1073/PNAS.0809645106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation