2W7X
Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019
Summary for 2W7X
Entry DOI | 10.2210/pdb2w7x/pdb |
Related | 1GXC 2CN5 2CN8 2W0J |
Descriptor | SERINE/THREONINE-PROTEIN KINASE CHK2, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | co-crystal structure, kinase, nucleus, magnesium, cell cycle, atp-binding, li-fraumeni syndrome, serine/threonine-protein kinase, disease mutation, nucleotide-binding, transferase, potentiation, metal-binding, proto-oncogene, phosphoprotein, chk2 inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017 |
Total number of polymer chains | 1 |
Total formula weight | 37152.06 |
Authors | Jobson, A.G.,Lountos, G.T.,Lorenzi, P.L.,Llamas, J.,Connelly, J.,Tropea, J.E.,Onda, A.,Kondapaka, S.,Zhang, G.,Caplen, N.J.,Caredellina, J.H.,Monks, A.,Self, C.,Waugh, D.S.,Shoemaker, R.H.,Pommier, Y. (deposition date: 2009-01-06, release date: 2009-09-22, Last modification date: 2023-12-13) |
Primary citation | Jobson, A.G.,Lountos, G.T.,Lorenzi, P.L.,Llamas, J.,Connelly, J.,Cerna, D.,Tropea, J.E.,Onda, A.,Zoppoli, G.,Kondapaka, S.,Zhang, G.,Caplen, N.J.,Cardellina, J.H.,Yoo, S.S.,Monks, A.,Self, C.,Waugh, D.S.,Shoemaker, R.H.,Pommier, Y. Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019. J.Pharmacol.Exp.Ther., 331:816-, 2009 Cited by PubMed: 19741151DOI: 10.1124/JPET.109.154997 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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