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2W7X

Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019

Summary for 2W7X
Entry DOI10.2210/pdb2w7x/pdb
Related1GXC 2CN5 2CN8 2W0J
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK2, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsco-crystal structure, kinase, nucleus, magnesium, cell cycle, atp-binding, li-fraumeni syndrome, serine/threonine-protein kinase, disease mutation, nucleotide-binding, transferase, potentiation, metal-binding, proto-oncogene, phosphoprotein, chk2 inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains1
Total formula weight37152.06
Authors
Primary citationJobson, A.G.,Lountos, G.T.,Lorenzi, P.L.,Llamas, J.,Connelly, J.,Cerna, D.,Tropea, J.E.,Onda, A.,Zoppoli, G.,Kondapaka, S.,Zhang, G.,Caplen, N.J.,Cardellina, J.H.,Yoo, S.S.,Monks, A.,Self, C.,Waugh, D.S.,Shoemaker, R.H.,Pommier, Y.
Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019.
J.Pharmacol.Exp.Ther., 331:816-, 2009
Cited by
PubMed: 19741151
DOI: 10.1124/JPET.109.154997
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.07 Å)
Structure validation

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