2W7O

Structure and Activity of Bypass Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-oxodeoxyguanosine Adduct

Summary for 2W7O

• Entry DOI: 10.2210/pdb2w7o/pdb
• Related: 1T94 2W7P
• Descriptor: DNA POLYMERASE KAPPA, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3', 5'-D(TP*CP*AP*CP*8OGP*GP*AP*AP*TP*CP*CP*TP* TP*CP*CP*CP*CP*C)-3', ... (6 entities in total)
• Functional Keywords: 8-oxo-2p-deoxy-guanosine-5p-monophosphate, translesion dna polymerase, human dna polymerase kappa, dgtp, dna repair, dna damage, dna-binding protein, dna binding protein
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: Q9UBT6
• Total number of polymer chains: 6
• Total formula weight: 136221.56

Authors

Irimia, A.,Egli, M. (deposition date: 2008-12-23, release date: 2009-06-16, Last modification date: 2023-12-13)

• Primary citation: Irimia, A.,Eoff, R.L.,Guengerich, F.P.,Egli, M.; Structural and Functional Elucidation of the Mechanism Promoting Error-Prone Synthesis by Human DNA Polymerase Kappa Opposite the 7,8-Dihydro-8-Oxo-2'-Deoxyguanosine Adduct.; J.Biol.Chem., 284:22467-, 2009; PubMed: 19542228; DOI: 10.1074/JBC.M109.003905

Experimental method

X-RAY DIFFRACTION (3.16 Å)