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2W71

Crystal structure of Biotin carboxylase from E. coli in complex with the imidazole-pyrimidine inhibitor

Summary for 2W71
Entry DOI10.2210/pdb2w71/pdb
Related1BNC 1DV1 1DV2 1K69 2GPS 2GPW 2J9G 2V58 2V59 2V5A 2VR1 2W6M 2W6N 2W6O 2W6P 2W6Q 2W6Z 2W70 2W7C
DescriptorBIOTIN CARBOXYLASE, CHLORIDE ION, 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine, ... (4 entities in total)
Functional Keywordsligase, atp-binding, fatty acid biosynthesis, nucleotide-binding, lipid synthesis, atp-grasp domain, fragment screening
Biological sourceESCHERICHIA COLI
Total number of polymer chains2
Total formula weight99512.62
Authors
Mochalkin, I.,Miller, J.R. (deposition date: 2008-12-19, release date: 2009-05-19, Last modification date: 2023-12-13)
Primary citationMochalkin, I.,Miller, J.R.,Narasimhan, L.S.,Thanabal, V.,Erdman, P.,Cox, P.,Prasad, J.V.,Lightle, S.,Huband, M.,Stover, K.
Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.
Acs Chem.Biol., 4:473-, 2009
Cited by
PubMed: 19413326
DOI: 10.1021/CB9000102
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.99 Å)
Structure validation

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