2W0J

Crystal structure of Chk2 in complex with NSC 109555, a specific inhibitor

Summary for 2W0J

Entry DOI	10.2210/pdb2w0j/pdb
Related	1GXC 2CN5 2CN8
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK2, 4,4'-DIACETYLDIPHENYLUREA-BIS(GUANYLHYDRAZONE), NITRATE ION, ... (4 entities in total)
Functional Keywords	chk2 inhibitor, oncology, kinase, structure-assisted drug design, transferase, nucleotide-binding, li-fraumeni syndrome, serine/threonine-protein kinase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains	1
Total formula weight	37032.70
Authors	Lountos, G.T.,Tropea, J.E.,Zhang, D.,Jobson, A.G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S. (deposition date: 2008-08-18, release date: 2009-02-10, Last modification date: 2023-12-13)
Primary citation	Lountos, G.T.,Tropea, J.E.,Zhang, D.,Jobson, A.G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S. Crystal Structure of Checkpoint Kinase 2 in Complex with Nsc 109555, a Potent and Selective Inhibitor Protein Sci., 18:92-, 2009 Cited by PubMed: 19177354 DOI: 10.1002/PRO.16 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation