2W0D

Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.

Summary for 2W0D

Entry DOI	10.2210/pdb2w0d/pdb
Related	1JIZ 1JK3 1OS2 1OS9 1RMZ 1ROS 1UTT 1UTZ 1Y93 1YCM 1Z3J
Descriptor	MACROPHAGE METALLOELASTASE, ZINC ION, CALCIUM ION, ... (8 entities in total)
Functional Keywords	glycoprotein, metal-binding, metalloprotease, secreted, hydrolase, hydroxamate, extracellular matrix, copd, mmp-12, zymogen
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	4
Total formula weight	76337.88
Authors	Isaksson, J.,Nystrom, S.,Derbyshire, D.J.,Wallberg, H.,Agback, T.,Kovacs, H.,Bertini, I.,Felli, I.C. (deposition date: 2008-08-13, release date: 2009-03-03, Last modification date: 2019-05-22)
Primary citation	Isaksson, J.,Nystrom, S.,Derbyshire, D.J.,Wallberg, H.,Agback, T.,Kovacs, H.,Bertini, I.,Felli, I.C. Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? a Case Study of Metalloproteinases. J.Med.Chem., 52:1712-, 2009 Cited by PubMed: 19239231 DOI: 10.1021/JM801388Q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation