2VZ2

Human MAO B in complex with mofegiline

Summary for 2VZ2

Entry DOI	10.2210/pdb2vz2/pdb
Related	1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C70 2C72 2C73 2C75 2C76 2V5Z 2V60 2V61 2VRL 2VRM
Descriptor	AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE, ... (5 entities in total)
Functional Keywords	oxidoreductase, inhibitor binding, flavoprotein, mitochondrion, transmembrane, human monoamine oxidase, mitochondrion outer membrane, fad, flavin, membrane, mofegiline, acetylation
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
Total number of polymer chains	2
Total formula weight	120274.10
Authors	Bonivento, D.,Mattevi, A. (deposition date: 2008-07-29, release date: 2008-12-16, Last modification date: 2023-12-13)
Primary citation	Milczek, E.M.,Bonivento, D.,Binda, C.,Mattevi, A.,McDonald, I.A.,Edmondson, D.E. Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B. J. Med. Chem., 51:8019-8026, 2008 Cited by PubMed: 19053775 DOI: 10.1021/jm8011867 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation