2VYA
Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750
Summary for 2VYA
Entry DOI | 10.2210/pdb2vya/pdb |
Related | 1MT5 |
Descriptor | FATTY-ACID AMIDE HYDROLASE 1, UNKNOWN ATOM OR ION, 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid, ... (5 entities in total) |
Functional Keywords | hydrolase, fatty acid amide hydrolyse, golgi apparatus, endoplasmic reticulum, inhibitor, drug- like, transmembrane, faah, chimera, membrane, covalent, humanized |
Biological source | RATTUS NORVEGICUS (RAT) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
Total number of polymer chains | 2 |
Total formula weight | 130016.57 |
Authors | Mileni, M.,Johnson, D.S.,Wang, Z.,Everdeen, D.S.,Liimatta, M.,Pabst, B.,Bhattacharya, K.,Nugent, R.A.,Kamtekar, S.,Cravatt, B.F.,Ahn, K.,Stevens, R.C. (deposition date: 2008-07-22, release date: 2008-09-09, Last modification date: 2023-12-13) |
Primary citation | Mileni, M.,Johnson, D.S.,Wang, Z.,Everdeen, D.S.,Liimatta, M.,Pabst, B.,Bhattacharya, K.,Nugent, R.A.,Kamtekar, S.,Cravatt, B.F.,Ahn, K.,Stevens, R.C. Structure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion. Proc.Natl.Acad.Sci.USA, 105:12820-, 2008 Cited by PubMed: 18753625DOI: 10.1073/PNAS.0806121105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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