2VX3

Crystal structure of the human dual specificity tyrosine- phosphorylation-regulated kinase 1A

Summary for 2VX3

• Entry DOI: 10.2210/pdb2vx3/pdb
• Related: 2WO6
• Descriptor: DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION- REGULATED KINASE 1A, N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: serine/threonine-protein kinase, minibrain homolog, nucleotide-binding, transferase, phosphoprotein, tyrosine-protein kinase, casp8, kinase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus speckle: Q13627
• Total number of polymer chains: 4
• Total formula weight: 183315.20

Authors

Roos, A.K.,Soundararajan, M.,Pike, A.C.W.,Federov, O.,King, O.,Burgess-Brown, N.,Philips, C.,Filippakopoulos, P.,Arrowsmith, C.H.,Wikstrom, M.,Edwards, A.,von Delft, F.,Bountra, C.,Knapp, S. (deposition date: 2008-06-30, release date: 2008-09-16, Last modification date: 2023-12-13)

• Primary citation: Soundararajan, M.,Roos, A.K.,Savitsky, P.,Filippakopoulos, P.,Kettenbach, A.N.,Olsen, J.V.,Gerber, S.A.,Eswaran, J.,Knapp, S.,Elkins, J.M.; Structures of Down Syndrome Kinases, Dyrks, Reveal Mechanisms of Kinase Activation and Substrate Recognition.; Structure, 21:986-, 2013; PubMed: 23665168; DOI: 10.1016/J.STR.2013.03.012

Experimental method

X-RAY DIFFRACTION (2.4 Å)