2VRX

Structure of Aurora B kinase in complex with ZM447439

Summary for 2VRX

Entry DOI	10.2210/pdb2vrx/pdb
Related	2BFX 2BFY 2VGO 2VGP
Descriptor	SERINE/THREONINE-PROTEIN KINASE 12-A, INNER CENTROMERE PROTEIN A, N-(4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}phenyl)benzamide, ... (4 entities in total)
Functional Keywords	serine/threonine-protein kinase, kinase, nucleus, mitosis, magnesium, cell cycle/transferase, centromere, microtubule, atp-binding, transferase, anti-cancer drug target, phosphoprotein, protein kinase, nucleotide-binding, coiled coil, cell division, metal-binding, cell cycle-transferase complex
Biological source	XENOPUS LAEVIS (AFRICAN CLAWED FROG) More
Cellular location	Nucleus: Q6DE08 Chromosome, centromere: O13024
Total number of polymer chains	4
Total formula weight	78284.39
Authors	Girdler, F.,Sessa, F.,Patercoli, S.,Villa, F.,Ridgway, E.,Musacchio, A.,Taylor, S.S. (deposition date: 2008-04-16, release date: 2008-07-01, Last modification date: 2011-07-13)
Primary citation	Girdler, F.,Sessa, F.,Patercoli, S.,Villa, F.,Musacchio, A.,Taylor, S.S. Molecular Basis of Drug Resistance in Aurora Kinases. Chem.Biol., 15:552-, 2008 Cited by PubMed: 18559266 DOI: 10.1016/J.CHEMBIOL.2008.04.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation