2VJ2

Human Jagged-1, domains DSL and EGFs1-3

Summary for 2VJ2

• Entry DOI: 10.2210/pdb2vj2/pdb
• Related: 2CAO
• Descriptor: JAGGED-1, D-MALATE (3 entities in total)
• Functional Keywords: signalling, polymorphism, glycoprotein, extracellular, developmental protein, notch signaling pathway, egf, dsl, notch, jagged, calcium, membrane, protein-binding, transmembrane, egf-like domain, disease mutation, protein binding
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Membrane; Single-pass type I membrane protein: P78504
• Total number of polymer chains: 2
• Total formula weight: 37796.26

Authors

Johnson, S.,Cordle, J.,Tay, J.Z.,Roversi, P.,Handford, P.A.,Lea, S.M. (deposition date: 2007-12-06, release date: 2008-07-29, Last modification date: 2011-07-13)

• Primary citation: Cordle, J.,Johnson, S.,Tay, J.Z.,Roversi, P.,Wilkin, M.B.,De Madrid, B.H.,Shimizu, H.,Jensen, S.,Whiteman, P.,Jin, B.,Redfield, C.,Baron, M.,Lea, S.M.,Handford, P.A.; A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.; Nat.Struct.Mol.Biol., 15:849-, 2008; PubMed: 18660822; DOI: 10.1038/NSMB.1457

Experimental method

X-RAY DIFFRACTION (2.5 Å)