2VHF

Structure of the CYLD USP domain

Summary for 2VHF

Entry DOI	10.2210/pdb2vhf/pdb
Related	1IXD 1WHL 1WHM
Descriptor	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION (3 entities in total)
Functional Keywords	cytokine signalling, linkage specificity, deubiquitinating enzyme, lys63- linked, anti-oncogene, thiol protease, cell signalling, phosphorylation, zn-binding domain, ubiquitin, cell cycle, usp domain, cross-brace, nf-kb, b-box, protease, hydrolase, cytoplasm, alternative splicing, ubl conjugation pathway
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9NQC7
Total number of polymer chains	2
Total formula weight	86952.00
Authors	Komander, D.,Lord, C.J.,Scheel, H.,Swift, S.,Hofmann, K.,Ashworth, A.,Barford, D. (deposition date: 2007-11-21, release date: 2008-03-11, Last modification date: 2011-07-13)
Primary citation	Komander, D.,Lord, C.J.,Scheel, H.,Swift, S.,Hofmann, K.,Ashworth, A.,Barford, D. The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module Mol.Cell.Biol., 29:451-, 2008 Cited by PubMed: 18313383 DOI: 10.1016/J.MOLCEL.2007.12.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation