2VCP

Crystal structure of N-Wasp VC domain in complex with skeletal actin

Summary for 2VCP

Entry DOI	10.2210/pdb2vcp/pdb
Related	1ALM 1ATN 1EQY 1ESV 1H1V 1IJJ 1J6Z 1KXP 1LCU 1LOT 1M8Q 1MA9 1MVW 1NWK 1O18 1O19 1O1A 1O1B 1O1C 1O1D 1O1E 1O1F 1O1G 1P8Z 1QZ5 1QZ6 1RDW 1RFQ 1RGI 1S22 1SQK 1T44 1UY5 1WUA 1Y64 2A3Z 2A40 2A41 2A42 2A5X 2ASM 2ASO 2ASP 2D1K 2FF3 2FF6 2FXU 2V39
Descriptor	ACTIN, ALPHA SKELETAL MUSCLE, NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	actin-binding, transcription, muscle protein, nucleotide-binding, transcription regulation, methylation, atp-binding, cytoskeleton, phosphorylation, structural protein, wh2, wasp, actin, nucleus, twinning
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	104499.89
Authors	Gaucher, J.F.,Didry, D.,Carlier, M.F. (deposition date: 2007-09-26, release date: 2008-11-04, Last modification date: 2023-12-13)
Primary citation	Gaucher, J.F.,Mauge, C.,Didry, D.,Guichard, B.,Renault, L.,Carlier, M.F. Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. J. Biol. Chem., 287:34646-34659, 2012 Cited by PubMed: 22847007 DOI: 10.1074/jbc.M112.394361 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation