2VBG

The complex structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis with 2R-1-hydroxyethyl-deazaThDP

Summary for 2VBG

• Entry DOI: 10.2210/pdb2vbg/pdb
• Related: 2VBF
• Descriptor: BRANCHED-CHAIN ALPHA-KETOACID DECARBOXYLASE, MAGNESIUM ION, 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-[(1R)-1-HYDROXYETHYL]-3-METHYL-2-THIENYL}ETHYL TRIHYDROGEN DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: kdca, flavoprotein, thdp-dependent enzymes, thiamine pyrophosphate, lyase
• Biological source: LACTOCOCCUS LACTIS
• Total number of polymer chains: 2
• Total formula weight: 127796.43

Authors

Berthold, C.L.,Gocke, D.,Wood, M.D.,Leeper, F.,Pohl, M.,Schneider, G. (deposition date: 2007-09-12, release date: 2007-11-27, Last modification date: 2023-12-13)

• Primary citation: Berthold, C.L.,Gocke, D.,Wood, M.D.,Leeper, F.,Pohl, M.,Schneider, G.; Crystal Structure of the Branched-Chain Keto Acid Decarboxylase (Kdca) from Lactococcus Lactis Provides Insights Into the Structural Basis for the Chemo- and Enantioselective Carboligation Reaction; Acta Crystallogr.,Sect.D, 63:1217-, 2007; PubMed: 18084069; DOI: 10.1107/S0907444907050433

Experimental method

X-RAY DIFFRACTION (1.8 Å)