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2V7A

Crystal structure of the T315I Abl mutant in complex with the inhibitor PHA-739358

Summary for 2V7A
Entry DOI10.2210/pdb2v7a/pdb
Related1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2F4J 2FO0 2G2F 2G2H 2GQG
DescriptorPROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordskinase, nucleus, myristate, cytoplasm, manganese, cell adhesion, metal-binding, proto-oncogene, tyrosine-protein kinase, chromosomal rearrangement, transferase, lipoprotein, polymorphism, cytoskeleton, magnesium, sh2 domain, sh3 domain, atp-binding, nucleotide-binding, alternative splicing, phosphorylation, kinase inhibitor, t315i abl mutant
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight67283.31
Authors
Modugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J. (deposition date: 2007-07-27, release date: 2007-09-18, Last modification date: 2023-12-13)
Primary citationModugno, M.,Casale, E.,Soncini, C.,Rosettani, P.,Colombo, R.,Lupi, R.,Rusconi, L.,Fancelli, D.,Carpinelli, P.,Cameron, A.D.,Isacchi, A.,Moll, J.
Crystal Structure of the T315I Abl Mutant in Complex with the Aurora Kinases Inhibitor Pha-739358.
Cancer Res., 67:7987-, 2007
Cited by
PubMed: 17804707
DOI: 10.1158/0008-5472.CAN-07-1825
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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