2V0G
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A tRNA(leu) transcript with 5-FLUORO-1,3-DIHYDRO-1-HYDROXY-2,1- BENZOXABOROLE (AN2690) forming an adduct to the ribose of adenosine- 76 in the enzyme editing site.
Summary for 2V0G
Entry DOI | 10.2210/pdb2v0g/pdb |
Related | 1H3N 1OBC 1OBH 2BTE 2BYT 2V0C |
Descriptor | AMINOACYL-TRNA SYNTHETASE, TRNALEU, LEUCINE, ... (6 entities in total) |
Functional Keywords | class i aminoacyl- trna synthetase, protein biosynthesis, aminoacyl-trna synthetase, atp + l-leucine + trna (leu) gives amp + ppi l-leucyl-trna synthetase, metal-binding, nucleotide-binding zinc, ligase, editing, synthetase, atp-binding |
Biological source | THERMUS THERMOPHILUS More |
Total number of polymer chains | 4 |
Total formula weight | 258287.99 |
Authors | Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K. (deposition date: 2007-05-14, release date: 2007-07-03, Last modification date: 2023-12-13) |
Primary citation | Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K. An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site. Science, 316:1759-, 2007 Cited by PubMed: 17588934DOI: 10.1126/SCIENCE.1142189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.5 Å) |
Structure validation
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