2RL5

Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor

Summary for 2RL5

Entry DOI	10.2210/pdb2rl5/pdb
Descriptor	Vascular endothelial growth factor receptor 2, N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE (3 entities in total)
Functional Keywords	receptor tyrosine kinase, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphorylation, polymorphism, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	36776.51
Authors	Whittington, D.A.,Long, A.M.,Rose, P.,Zhao, H. (deposition date: 2007-10-18, release date: 2008-04-08, Last modification date: 2024-02-21)
Primary citation	La, D.S.,Belzile, J.,Bready, J.V.,Coxon, A.,Demelfi, T.,Doerr, N.,Estrada, J.,Flynn, J.C.,Flynn, S.R.,Graceffa, R.F.,Harriman, S.P.,Larrow, J.F.,Long, A.M.,Martin, M.W.,Morrison, M.J.,Patel, V.F.,Roveto, P.M.,Wang, L.,Weiss, M.M.,Whittington, D.A.,Teffera, Y.,Zhao, Z.,Polverino, A.J.,Harmange, J.C. Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis. J.Med.Chem., 51:1695-1705, 2008 Cited by PubMed: 18311900 DOI: 10.1021/jm701129j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation