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2RG6

Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11J

Summary for 2RG6
Entry DOI10.2210/pdb2rg6/pdb
DescriptorMitogen-activated protein kinase 14, 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide (3 entities in total)
Functional Keywordsserine/threonine-protein kinase, kinase, transferase, p38 map kinase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): Q16539
Total number of polymer chains1
Total formula weight43022.03
Authors
Sack, J.S. (deposition date: 2007-10-02, release date: 2008-01-15, Last modification date: 2024-02-21)
Primary citationHynes, J.,Dyckman, A.J.,Lin, S.,Wrobleski, S.T.,Wu, H.,Gillooly, K.M.,Kanner, S.B.,Lonial, H.,Loo, D.,McIntyre, K.W.,Pitt, S.,Shen, D.R.,Shuster, D.J.,Yang, X.,Zhang, R.,Behnia, K.,Zhang, H.,Marathe, P.H.,Doweyko, A.M.,Tokarski, J.S.,Sack, J.S.,Pokross, M.,Kiefer, S.E.,Newitt, J.A.,Barrish, J.C.,Dodd, J.,Schieven, G.L.,Leftheris, K.
Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors
J.Med.Chem., 51:4-16, 2008
Cited by
PubMed: 18072718
DOI: 10.1021/jm7009414
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.72 Å)
Structure validation

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