2RFN

x-ray structure of c-Met with inhibitor.

Summary for 2RFN

Entry DOI	10.2210/pdb2rfn/pdb
Related	2RFS
Descriptor	Hepatocyte growth factor receptor, 2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3H)-one (3 entities in total)
Functional Keywords	c-met hgf receptor tyrosine kinse kinase domain, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphorylation, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P08581
Total number of polymer chains	2
Total formula weight	71915.17
Authors	Bellon, S.F.,Kaplan-Lefko, P.,Yang, Y.,Zhang, Y.,Moriguchi, J.,Dussault, I. (deposition date: 2007-10-01, release date: 2007-11-06, Last modification date: 2023-08-30)
Primary citation	Bellon, S.F.,Kaplan-Lefko, P.,Yang, Y.,Zhang, Y.,Moriguchi, J.,Rex, K.,Johnson, C.W.,Rose, P.E.,Long, A.M.,O'Connor, A.B.,Gu, Y.,Coxon, A.,Kim, T.S.,Tasker, A.,Burgess, T.L.,Dussault, I. c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J.Biol.Chem., 283:2675-2683, 2008 Cited by PubMed: 18055465 DOI: 10.1074/jbc.M705774200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation