2RFE

Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide

Summary for 2RFE

Entry DOI	10.2210/pdb2rfe/pdb
Related	2RF9 2RFD
Descriptor	Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1 (3 entities in total)
Functional Keywords	kinase domain, inhibition, dimer, alternative splicing, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation, cytoplasm
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 Cytoplasm : Q9UJM3
Total number of polymer chains	6
Total formula weight	156370.83
Authors	Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J. (deposition date: 2007-09-28, release date: 2007-12-04, Last modification date: 2023-08-30)
Primary citation	Zhang, X.,Pickin, K.A.,Bose, R.,Jura, N.,Cole, P.A.,Kuriyan, J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450:741-744, 2007 Cited by PubMed: 18046415 DOI: 10.1038/nature05998 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation