2REA

Crystal structures of C2ALPHA-PI3 kinase PX-domain domain indicate conformational change associated with ligand binding.

Summary for 2REA

Entry DOI	10.2210/pdb2rea/pdb
Related	2RED 2ar5
Descriptor	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (2 entities in total)
Functional Keywords	px domain, pi3k, kinase, transferase, phosphorylation, nuclear protein, phosphoinositide, cytoplasm, cytoplasmic vesicle, golgi apparatus, membrane, nucleus, polymorphism
Biological source	Homo sapiens (human)
Cellular location	Cell membrane: O00443
Total number of polymer chains	1
Total formula weight	14375.57
Authors	Parkinson, G.N.,Vines, D.,Driscoll, P.C.,Djordjevic, S. (deposition date: 2007-09-26, release date: 2007-11-27, Last modification date: 2023-08-30)
Primary citation	Parkinson, G.N.,Vines, D.,Driscoll, P.C.,Djordjevic, S. Crystal structures of PI3K-C2alpha PX domain indicate conformational change associated with ligand binding Bmc Struct.Biol., 8:13-13, 2008 Cited by PubMed: 18312637 DOI: 10.1186/1472-6807-8-13 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation