2RD7

Human Complement Membrane Attack Proteins Share a Common Fold with Bacterial Cytolysins

Summary for 2RD7

Entry DOI	10.2210/pdb2rd7/pdb
Descriptor	Complement component C8 alpha chain, Complement component C8 gamma chain, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	membrane attack system, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, egf-like domain, glycoprotein, immune response, innate immunity, membrane attack complex, polymorphism, secreted, immune system
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P07357 P07360
Total number of polymer chains	2
Total formula weight	62281.59
Authors	Slade, D.J.,Lovelace, L.L.,Chruszcz, M.,Minor, W.,Lebioda, L.,Sodetz, J.M. (deposition date: 2007-09-21, release date: 2008-05-27, Last modification date: 2024-04-03)
Primary citation	Lovelace, L.L.,Cooper, C.L.,Sodetz, J.M.,Lebioda, L. Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement. J. Biol. Chem., 286:17585-17592, 2011 Cited by PubMed: 21454577 DOI: 10.1074/jbc.M111.219766 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation