2R7E

Crystal Structure Analysis of Coagulation Factor VIII

Summary for 2R7E

• Entry DOI: 10.2210/pdb2r7e/pdb
• Related: 1d7p
• Descriptor: Coagulation factor VIII, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: ceruloplasmin fold, cupper protein fold, c2 domain fold, acute phase, blood coagulation, disease mutation, glycoprotein, hemophilia, metal-binding, secreted, sulfation, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 176523.07

Authors

Stoddard, B.L.,Shen, B.W. (deposition date: 2007-09-07, release date: 2008-04-15, Last modification date: 2023-08-30)

• Primary citation: Shen, B.W.,Spiegel, P.C.,Chang, C.H.,Huh, J.W.,Lee, J.S.,Kim, J.,Kim, Y.H.,Stoddard, B.L.; The tertiary structure and domain organization of coagulation factor VIII.; Blood, 111:1240-1247, 2008; PubMed: 17965321; DOI: 10.1182/blood-2007-08-109918

Experimental method

X-RAY DIFFRACTION (3.7 Å)