2R7B

Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor

Summary for 2R7B

Entry DOI	10.2210/pdb2r7b/pdb
Descriptor	3-phosphoinositide-dependent protein kinase 1, SULFATE ION, 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine, ... (4 entities in total)
Functional Keywords	pdk1, dibenzonaphthyridine, inhibitor, signaling protein, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O15530
Total number of polymer chains	1
Total formula weight	36083.29
Authors	Olland, A.M. (deposition date: 2007-09-07, release date: 2008-09-09, Last modification date: 2024-03-27)
Primary citation	Gopalsamy, A.,Shi, M.,Boschelli, D.H.,Williamson, R.,Olland, A.M.,Hu, Y.,Krishnamurthy, G.,Han, X.,Arndt, K.,Guo, B. Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors. J.Med.Chem., 50:5547-5549, 2007 Cited by PubMed: 17941624 DOI: 10.1021/jm070851i PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation