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2R6N

Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K

Summary for 2R6N
Entry DOI10.2210/pdb2r6n/pdb
Related1U9V 1U9W 1U9X
DescriptorCathepsin K, 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (3 entities in total)
Functional Keywordscovalent bond to inhibitor, disease mutation, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Biological sourceHomo sapiens (human)
Cellular locationLysosome: P43235
Total number of polymer chains1
Total formula weight24156.31
Authors
Cowan-Jacob, S.W.,Ramage, P.,Mathis, B.,Geisse, S. (deposition date: 2007-09-06, release date: 2007-11-06, Last modification date: 2017-10-25)
Primary citationTeno, N.,Miyake, T.,Ehara, T.,Irie, O.,Sakaki, J.,Ohmori, O.,Gunji, H.,Matsuura, N.,Masuya, K.,Hitomi, Y.,Nonomura, K.,Horiuchi, M.,Gohda, K.,Iwasaki, A.,Umemura, I.,Tada, S.,Kometani, M.,Iwasaki, G.,Cowan-Jacob, S.W.,Missbach, M.,Lattmann, R.,Betschart, C.
Novel scaffold for cathepsin K inhibitors.
Bioorg.Med.Chem.Lett., 17:6096-6100, 2007
Cited by
PubMed: 17911019
DOI: 10.1016/j.bmcl.2007.09.047
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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