2R69

Crystal structure of Fab 1A1D-2 complexed with E-DIII of Dengue virus at 3.8 angstrom resolution

2R69 の概要

• エントリーDOI: 10.2210/pdb2r69/pdb
• 分子名称: Major envelope protein E, Heavy chain of 1A1D-2, Light chain of 1A1D-2 (3 entities in total)
• 機能のキーワード: fab-antigen complex, capsid protein, cleavage on pair of basic residues, core protein, envelope protein, glycoprotein, membrane, transmembrane, virion, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Dengue virus 2 Thailand/16681/84; 詳細
• 細胞内の位置: Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted : P18356
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 57272.09

構造登録者

Lok, S.M.,Kostyuchenko, V.K.,Nybakken, G.E.,Holdaway, H.A.,Battisti, A.J.,Sukupolvi-petty, S.,Sedlak, D.,Fremont, D.H.,Chipman, P.R.,Roehrig, J.T.,Diamond, M.S.,Kuhn, R.J.,Rossmann, M.G. (登録日: 2007-09-05, 公開日: 2007-12-25, 最終更新日: 2018-01-24)

• 主引用文献: Lok, S.M.,Kostyuchenko, V.,Nybakken, G.E.,Holdaway, H.A.,Battisti, A.J.,Sukupolvi-Petty, S.,Sedlak, D.,Fremont, D.H.,Chipman, P.R.,Roehrig, J.T.,Diamond, M.S.,Kuhn, R.J.,Rossmann, M.G.; Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.; Nat.Struct.Mol.Biol., 15:312-317, 2008; PubMed: 18264114; DOI: 10.1038/nsmb.1382

実験手法

X-RAY DIFFRACTION (3.8 Å)