2QZO

Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with WAY-169916

Summary for 2QZO

Entry DOI	10.2210/pdb2qzo/pdb
Related	2QXS
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol, ... (5 entities in total)
Functional Keywords	protein-ligand complex, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 P03372 Nucleus : Q8BN74
Total number of polymer chains	4
Total formula weight	62829.89
Authors	Bruning, J.B.,Gil, G.,Nowak, J.,Katzenellenbogen, J.,Nettles, K.W. (deposition date: 2007-08-16, release date: 2008-08-26, Last modification date: 2023-08-30)
Primary citation	Bruning, J.B.,Parent, A.A.,Gil, G.,Zhao, M.,Nowak, J.,Pace, M.C.,Smith, C.L.,Afonine, P.V.,Adams, P.D.,Katzenellenbogen, J.A.,Nettles, K.W. Coupling of receptor conformation and ligand orientation determine graded activity. Nat.Chem.Biol., 6:837-843, 2010 Cited by PubMed: 20924370 DOI: 10.1038/nchembio.451 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.72 Å)

Structure validation