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2QWF

THE X-RAY STRUCTURE OF A COMPLEX OF N-ACETYL-4-GUANIDINO-6-METHYL(PROPYL)CARBOXAMIDE-4,5-DIHYDRO-2H-PYRAN-2-CARBOXYLIC ACID AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE

Summary for 2QWF
Entry DOI10.2210/pdb2qwf/pdb
DescriptorNEURAMINIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywordsneuraminidase, influenza protein, drug resistant variant, sialic acid analogues, dana anologues, glycosylated protein, hydrolase
Biological sourceInfluenza A virus
Cellular locationVirion membrane (By similarity): P03472
Total number of polymer chains1
Total formula weight45997.99
Authors
Varghese, J.N. (deposition date: 1998-04-07, release date: 1998-11-11, Last modification date: 2021-11-03)
Primary citationVarghese, J.N.,Smith, P.W.,Sollis, S.L.,Blick, T.J.,Sahasrabudhe, A.,McKimm-Breschkin, J.L.,Colman, P.M.
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure, 6:735-746, 1998
Cited by
PubMed: 9655825
DOI: 10.1016/S0969-2126(98)00075-6
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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