2QWC

THE X-RAY STRUCTURE OF A COMPLEX OF NEU5AC2EN AND A DRUG RESISTANT VARIANT R292K OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE

Summary for 2QWC

Entry DOI	10.2210/pdb2qwc/pdb
Descriptor	NEURAMINIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	neuraminidase, influenza protein, drug resistant variant, sialic acid, dana, glycosylated protein, hydrolase
Biological source	Influenza A virus
Cellular location	Virion membrane (By similarity): P03472
Total number of polymer chains	1
Total formula weight	45947.88
Authors	Varghese, J.N. (deposition date: 1998-04-07, release date: 1998-11-11, Last modification date: 2024-04-03)
Primary citation	Varghese, J.N.,Smith, P.W.,Sollis, S.L.,Blick, T.J.,Sahasrabudhe, A.,McKimm-Breschkin, J.L.,Colman, P.M. Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure, 6:735-746, 1998 Cited by PubMed: 9655825 DOI: 10.1016/S0969-2126(98)00075-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation