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2QU6

Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor

Summary for 2QU6
Entry DOI10.2210/pdb2qu6/pdb
Related2QU5
DescriptorVascular endothelial growth factor receptor 2, SULFATE ION, 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide, ... (4 entities in total)
Functional Keywordsreceptor tyrosine kinase, kdr, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, membrane, nucleotide-binding, phosphorylation, polymorphism, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
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Cellular locationCell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains2
Total formula weight73681.17
Authors
Whittington, D.A.,Kim, J.L.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2007-08-03, release date: 2007-09-25, Last modification date: 2024-02-21)
Primary citationPotashman, M.H.,Bready, J.,Coxon, A.,Demelfi, T.M.,Dipietro, L.,Doerr, N.,Elbaum, D.,Estrada, J.,Gallant, P.,Germain, J.,Gu, Y.,Harmange, J.C.,Kaufman, S.A.,Kendall, R.,Kim, J.L.,Kumar, G.N.,Long, A.M.,Neervannan, S.,Patel, V.F.,Polverino, A.,Rose, P.,Plas, S.V.,Whittington, D.,Zanon, R.,Zhao, H.
Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50:4351-4373, 2007
Cited by
PubMed: 17696416
DOI: 10.1021/jm070034i
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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