2QTZ

Crystal Structure of the NADP+-bound FAD-containing FNR-like Module of Human Methionine Synthase Reductase

Summary for 2QTZ

• Entry DOI: 10.2210/pdb2qtz/pdb
• Related: 2QTL
• Descriptor: Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: alpha-beta-alpha structural motif, flattened antiparallel beta barrel, flexible hinge region, connecting domain, fad-binding region, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform B: Cytoplasm. Isoform C: Cytoplasm. Isoform A: Cytoplasm : Q9UBK8
• Total number of polymer chains: 1
• Total formula weight: 61585.47

Authors

Wolthers, K.R.,Lou, X.,Toogood, H.S.,Leys, D.,Scrutton, N.S. (deposition date: 2007-08-02, release date: 2007-11-13, Last modification date: 2022-12-21)

• Primary citation: Wolthers, K.R.,Lou, X.,Toogood, H.S.,Leys, D.,Scrutton, N.S.; Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry; Biochemistry, 46:11833-11844, 2007; PubMed: 17892308; DOI: 10.1021/bi701209p

Experimental method

X-RAY DIFFRACTION (1.9 Å)