2QTW

The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain

Summary for 2QTW

• Entry DOI: 10.2210/pdb2qtw/pdb
• Descriptor: Proprotein convertase subtilisin/kexin type 9 Propeptide, Proprotein convertase subtilisin/kexin type 9, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: pro-protein convertase, coronary heart disease, hypercholesterolemia, low density lipoprotein receptor, autocatalytic cleavage, cholesterol metabolism, disease mutation, glycoprotein, hydrolase, lipid metabolism, phosphorylation, protease, secreted, serine protease, steroid metabolism, zymogen
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 72553.64

Authors

Hampton, E.N.,Knuth, M.W.,Li, J.,Harris, J.L.,Lesley, S.A.,Spraggon, G. (deposition date: 2007-08-02, release date: 2007-09-18, Last modification date: 2020-07-29)

• Primary citation: Hampton, E.N.,Knuth, M.W.,Li, J.,Harris, J.L.,Lesley, S.A.,Spraggon, G.; The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.; Proc.Natl.Acad.Sci.Usa, 104:14604-14609, 2007; PubMed: 17804797; DOI: 10.1073/pnas.0703402104

Experimental method

X-RAY DIFFRACTION (1.9 Å)