2QR9

Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed with an Oxabicyclic Derivative Compound

Summary for 2QR9

Entry DOI	10.2210/pdb2qr9/pdb
Related	2QSE 2QXM
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate, ... (4 entities in total)
Functional Keywords	protein-ligand complex, dna-binding, lipid-binding, metal-binding, nucleus, phosphorylation, receptor, steroid-binding, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372 Nucleus : Q8BN74
Total number of polymer chains	4
Total formula weight	62721.70
Authors	Nettles, K.W.,Bruning, J.B. (deposition date: 2007-07-27, release date: 2008-03-18, Last modification date: 2023-08-30)
Primary citation	Nettles, K.W.,Bruning, J.B.,Gil, G.,Nowak, J.,Sharma, S.K.,Hahm, J.B.,Kulp, K.,Hochberg, R.B.,Zhou, H.,Katzenellenbogen, J.A.,Katzenellenbogen, B.S.,Kim, Y.,Joachmiak, A.,Greene, G.L. NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nat.Chem.Biol., 4:241-247, 2008 Cited by PubMed: 18344977 DOI: 10.1038/nchembio.76 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation