2QQH

Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense

Summary for 2QQH

• Entry DOI: 10.2210/pdb2qqh/pdb
• Descriptor: Complement component C8 alpha chain, SULFATE ION, NICKEL (II) ION, ... (4 entities in total)
• Functional Keywords: macpf, membrane perforation, cleavage on pair of basic residues, complement alternate pathway, complement pathway, cytolysis, egf-like domain, glycoprotein, immune response, innate immunity, membrane attack complex, polymorphism, secreted, immune system, membrane protein
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P07357
• Total number of polymer chains: 1
• Total formula weight: 37890.10

Authors

Hadders, M.A.,Gros, P. (deposition date: 2007-07-26, release date: 2007-09-25, Last modification date: 2021-10-20)

• Primary citation: Hadders, M.A.,Beringer, D.X.,Gros, P.; Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.; Science, 317:1552-1554, 2007; PubMed: 17872444; DOI: 10.1126/science.1147103

Experimental method

X-RAY DIFFRACTION (2.5 Å)