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2QP6

The crystal structure of the complex of hcaII with a bioreductive antitumor derivative

Summary for 2QP6
Entry DOI10.2210/pdb2qp6/pdb
Related1CA2 2QO8 2QOA
DescriptorCarbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total)
Functional Keywordscarbonic anhydrase ii, lyase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P00918
Total number of polymer chains1
Total formula weight30017.65
Authors
D'Ambrosio, K.,De Simone, G. (deposition date: 2007-07-23, release date: 2008-06-03, Last modification date: 2023-08-30)
Primary citationD'Ambrosio, K.,Vitale, R.M.,Dogne, J.M.,Masereel, B.,Innocenti, A.,Scozzafava, A.,De Simone, G.,Supuran, C.T.
Carbonic Anhydrase Inhibitors: Bioreductive Nitro-Containing Sulfonamides with Selectivity for Targeting the Tumor Associated Isoforms IX and XII.
J.Med.Chem., 51:3230-3237, 2008
Cited by
PubMed: 18481843
DOI: 10.1021/jm800121c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.45 Å)
Structure validation

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