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2QGD

Human transthyretin (TTR) complexed with 2-(3,5-Dibromo-4-hydroxyphenyl)benzoxazole

Summary for 2QGD
Entry DOI10.2210/pdb2qgd/pdb
DescriptorTransthyretin, 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOL (3 entities in total)
Functional Keywordstransthyretin, tetramer, amyloidogenesis inhibitors, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight28292.74
Authors
Connelly, S.,Wilson, I.A. (deposition date: 2007-06-28, release date: 2008-02-05, Last modification date: 2023-08-30)
Primary citationJohnson, S.M.,Connelly, S.,Wilson, I.A.,Kelly, J.W.
Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
J.Med.Chem., 51:260-270, 2008
Cited by
PubMed: 18095641
DOI: 10.1021/jm0708735
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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