2Q9G

Crystal structure of human cytochrome P450 46A1

Summary for 2Q9G

Entry DOI	10.2210/pdb2q9g/pdb
Related	2q9f
Descriptor	Cytochrome P450 46A1, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (4 entities in total)
Functional Keywords	cyp46a1, p450 46a1, p450, monooxygenase, cholesterol metabolic enzyme, oxidoreductase, heme
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2
Total number of polymer chains	1
Total formula weight	52925.76
Authors	White, M.A.,Mast, N.V.,Johnson, E.F.,Stout, C.D.,Pikuleva, I.A. (deposition date: 2007-06-12, release date: 2008-06-17, Last modification date: 2023-08-30)
Primary citation	Mast, N.,White, M.A.,Bjorkhem, I.,Johnson, E.F.,Stout, C.D.,Pikuleva, I.A. Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proc.Natl.Acad.Sci.Usa, 105:9546-9551, 2008 Cited by PubMed: 18621681 DOI: 10.1073/pnas.0803717105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation