2Q8S

X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist

Summary for 2Q8S

Entry DOI	10.2210/pdb2q8s/pdb
Related	2PRG
Descriptor	Peroxisome proliferator-activated receptor gamma, (2S)-3-{4-[3-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)PROPYL]PHENYL}-2-(1H-PYRROL-1-YL)PROPANOIC ACID (3 entities in total)
Functional Keywords	ligand-bound complex, hormone receptor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	62408.54
Authors	Ohren, J.F. (deposition date: 2007-06-11, release date: 2008-10-14, Last modification date: 2023-08-30)
Primary citation	Casimiro-Garcia, A.,Bigge, C.F.,Davis, J.A.,Padalino, T.,Pulaski, J.,Ohren, J.F.,McConnell, P.,Kane, C.D.,Royer, L.J.,Stevens, K.A.,Auerbach, B.J.,Collard, W.T.,McGregor, C.,Fakhoury, S.A.,Schaum, R.P.,Zhou, H. Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies. Bioorg.Med.Chem., 16:4883-4907, 2008 Cited by PubMed: 18394907 DOI: 10.1016/j.bmc.2008.03.043 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation