2Q7O

Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H

Summary for 2Q7O

Entry DOI	10.2210/pdb2q7o/pdb
Related	1rr6
Descriptor	Purine nucleoside phosphorylase, PHOSPHATE ION, 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, ... (4 entities in total)
Functional Keywords	purine nucleoside phosphorylase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton : P00491
Total number of polymer chains	1
Total formula weight	32546.10
Authors	Rinaldo-Matthis, A.,Almo, S.C.,Schramm, V.L. (deposition date: 2007-06-07, release date: 2008-01-15, Last modification date: 2023-08-30)
Primary citation	Rinaldo-Matthis, A.,Murkin, A.S.,Ramagopal, U.A.,Clinch, K.,Mee, S.P.,Evans, G.B.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase. J.Am.Chem.Soc., 130:842-844, 2008 Cited by PubMed: 18154341 DOI: 10.1021/ja710733g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation